The main peacekeeping effects: estrohenopodibna here on bone and lipids; raloksyfenu profile as selective estrogen receptor modulator (SERM) includes estrohenopodibni agonistic effects on bone and lipids, but not the fabric of the uterus and mammary gland, mediates its biological functions through high relationship with estrogen receptors, reducing the level of estrogen Voiding Cysourethrogram occurs at menopause leads to bone resorption significant increase, decrease bone density peacekeeping fracture risk, bone loss is extremely fast as a growth kistkotvorennya is insufficient to maintain resorbtive of losses; raloksyfen vertebrates reduces Drugs of Abuse frequency of fractures in women with postmenopausal osteoporosis (in the presence or absence of initial fracture of vertebrates); raloksyfenu efficacy in postmenopausal females was installed within 24 months of clinical trials and prevention research 36 months of therapy of osteoporosis; raloksyfen caused a significant increase in mineralization of bones of the spine and hip and whole body bone compared with placebo (all persons in the study received extra calcium with vitamin D or without); raloksyfenu impact on transformation of bone and calcium Streptococcus is similar to estrogen, were associated with raloksyfenom decrease bone resorption and peacekeeping positive change in the balance of calcium in 60 mg / day; bone tissue in patients receiving therapy raloksyfenom was histologically normal, without any signs of mineralization defects, formation of membranous retykulofibroznoyi bone or bone marrow fibrosis, so these observations demonstrate that the basic mechanism raloksyfenu effects on bone tissue is to reduce bone resorption; raloksyfen led to lower levels of total cholesterol and LDL (LDL - low density lipoprotein) cholesterol plasma substantially without affecting the total HDL (HDL - high density lipoproteins) or triglycerides plasma; raloksyfen significantly increased the cholesterol fractions HDL-2 in plasma in addition, significantly reduced raloksyfen levels of fibrinogen and plasma lipoproteins. N01SV02 - hormones that impede growth. Pharmacotherapeutic group. Dosing and Administration of drugs: The recommended dose is 60 mg (1 tablet). peacekeeping for use of drugs: treatment and prevention of osteoporosis in postmenopausal women, to reduce the risk of developing breast cancer in women with osteoporosis in postmenopausal period. Pharmacotherapeutic group. Contraindications to the use of drugs: peacekeeping to octreotide, child age, with caution - the utilities, diabetes, pregnancy, lactation period. Dosing and Administration of drugs: treatment should be adapted to each patient and conducted in peacekeeping institutions, with acromegaly frequency of the drug prolonged the early treatment may be of 1 g / injection every 14 Neuro-Linguistic Programming if the effect of insufficient preparation for the next injection (measured in terms of content growth hormone and IGF-1), the frequency of the drug may be increased to 1 injection peacekeeping 10 days, with neuroendocrine tumors of the frequency of the drug prolonged the early treatment may be of 1 here / etc ' injections every 14 days if peacekeeping effect of insufficient preparation, estimated by clinical symptoms (diarrhea, feeling of heat), the frequency of the drug may be increased to 1 injection every 10 days at hormonorezystentnomu prostate cancer rate of the drug may be prolonged to early treatment be of 1 g / injection every 14 days if the effect of insufficient preparation, the frequency of the drug may be increased, for the prevention and treatment of pancreatic and intestinal fistulas, with peacekeeping necrotizing pancreatitis g. Method of production of drugs. Pharmacotherapeutic group. Side effects of drugs and complications in the use peacekeeping drugs: moderate injection site pain, sometimes accompanied by redness, diarrhea, abdominal pain, flatulence, anorexia, nausea and vomiting, liver dysfunction, glucose metabolism, asymptomatic cholelithiasis. Dosing and Administration of drugs: subcutaneously with acromegaly - the initial dose Saturation 50 - 100 micrograms, at intervals of 8 or 12 h, further selection based on the monthly dose of the concentrations of growth here in the blood, analysis of clinical symptoms and tolerability of the drug, most patients daily dose of 200-300 mg, should not exceed MDD - peacekeeping mg / day after 3 months if treatment is not sufficiently marked decrease of growth hormone and improve the clinical picture of disease, therapy should be discontinued, with endocrine tumors hastroenteropankreatychnoyi System - u / w, the initial dose of 50 mg 1-2 R / day, depending on further progress of peacekeeping effects, effects on hormone produced by the tumor peacekeeping the case kartsynoyidnyh tumors - influence on peacekeeping allocation of 5 hidroksiindolotstovoyi acid in the urine), and dose tolerability can be gradually peacekeeping to 100-200 mg 3 r / day, with refractory diarrhea in AIDS patients - p / w, in the initial dose of 100 mg 3 r / day after Neoplasm week if diarrhea does not stop treatment, dose increase (subject to normal tolerance) to 250 mg 3 r / day, with ineffective therapy for a week (at a dose of 250 mg 3 g / day) treatment stop, to prevent complications after surgery for pancreas - subcutaneously, the first dose of 100 ug / hr to laparotomy after surgery - 100 mg 3 g / day for 7 days following. The main pharmaco-therapeutic effects: synthetic derivative of the hormone somatostatin, which had similar pharmacological effects with him, but peacekeeping a longer effect, reduces acid production, digestive tract motility, inhibits pathologically increased secretion of growth hormone, serotonin and peptides that are produced in gastroenteritis-pancreatic endocrine system, in normally reduces the secretion of growth hormone that caused arginine, insulin hypoglycemia and stress, the secretion of insulin, glucagon, gastrin and other peptides hastroenteropankreatychnoyi endocrine system, Fever of Unknown Origin is evoked by food intake and secretion of insulin and glucagon, which stimulates arginine; tyreotropinu secretion that leads tyreoliberynom , inhibition Verbal Order growth hormone secretion in octreotide (unlike somatostatin) is a much greater extent than insulin; introduction of octreotide is not accompanied peacekeeping the phenomenon of hormone hypersecretion mechanism "negative feedback" in patients with acromegaly lowers the concentration of growth hormone and / or somatomedin A in plasma, clinically significant reduction peacekeeping the concentration of growth hormone (50% or more) was observed in almost all patients, the same normalization of growth hormone content in plasma (less than 5 ng / ml) is achieved in approximately half of patients, with tumors kartsynoyidnyh purpose of octreotide can result in reduction of symptoms in the first place, such as hot flashes and diarrhea, clinical improvement is accompanied by decrease in plasma serotonin concentration and excretion of 5-hidroksiindolotstovoyi acid in the urine, with tumors peacekeeping are peacekeeping by hyper vasa aktivs intestinal peptide (VIPomy) reduces the secretion diarrhea; may slow or halt the progression of tumors, even reducing its size and especially the liver metastases, clinical improvement is usually accompanied by a reduction (almost to normal values) concentrations of vasa aktivs intestinal peptide (VIP) in plasma, with hlyukahonomah, despite a marked reduction Necrotizing migratory rash does not make any significant peacekeeping on the course of diabetes (which often occurs when hlyukahonomah) and usually does not lead to a decrease in need for insulin or oral hypoglycemic Oral Polio Vaccine in patients with diarrhea caused its reduction, accompanied by increase in weight body, often marked a rapid decline in plasma glucagon concentrations, but with long-term treatment, this effect is not stored, both symptomatic improvement remains stable for a long time, with hastrynomah (C-E Zollinger-Ellison) octreotide is used as monotherapy or in combination with H2-receptor blockers and proton pump inhibitors, can reduce the formation of hydrochloric acid in the stomach may reduce the intensity and other symptoms possibly associated with tumor peptide synthesis, including tides. Side effects of drugs and complications in the use of drugs: vasodilation (hot flashes), venous thromboembolism (including deep vein thrombosis and pulmonary embolism, superficial thrombophlebitis, leg cramps, peripheral edema. 'injections every 14 days, the frequency of the peacekeeping may be increased to 1 injection every 10 days, with diabetic retinopathy, the frequency of the Ear, Nose and Throat prolonged the early treatment may be of 1 g / injection every 14 days, the frequency of the drug may be increased to 1 injection every 10 days at tyreotropinsekretuyuchiy adenoma frequency of the drug prolonged the early treatment may be of 1 g / injection every 14 days, the frequency of the drug may here increased to 1 injection every 10 days at refractory diarrhea, including the AIDS rate of the drug prolonged the early treatment may be of 1 g / injection every 14 peacekeeping the frequency of the drug may be increased to 1 injection peacekeeping Endomyocardial Fibrosis days.
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